A Rare Case of Behçet’s Disease Highlighting Uncommon Dilations: Case Report
DOI:
https://doi.org/10.52609/jmlph.v5i2.204Keywords:
Atypical, Behçet’s disease, Case Report, Thrombosis, Vascular DilationAbstract
Behçet’s disease (BD) is traditionally diagnosed based on clinical symptoms such as recurrent oral and genital ulcerations, eye and skin lesions, and, in some cases, a positive pathergy test. However, the clinical presentation of BD has evolved, with recent reports highlighting a broader spectrum of manifestations, including vascular involvement in nearly half of affected patients. Our report presents a unique case of a 42-year-old male with BD and atypical vascular involvement. This case is noteworthy due to the atypical vascular dilations, which extend beyond the vascular sites commonly observed in BD. It underscores the complex and diverse presentations of BD and highlights the importance of maintaining a high index of suspicion for atypical vascular involvement. The patient’s symptoms were effectively managed with immunomodulatory therapy, demonstrating the need for individualised treatment strategies. This report calls for further research to improve the understanding and management of such rare BD presentations, contributing valuable insights to the existing literature.
References
Adil A, Goyal A, Quint JM. Behcet disease. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 [cited 2025 Feb 27]. Available from: http://www.ncbi.nlm.nih.gov/books/NBK470257/
Dos Santos VM. Behçet’s disease and hemoptysis. Turk Thorac J. 2018 Oct;19(4):233–4.
Leonardo NM, McNeil J. Behcet’s disease: is there geographical variation? A review far from› the Silk Road. Int J Rheumatol. 2015;2015:945262.
Becatti M, Emmi G, Bettiol A, Silvestri E, Di Scala G, Taddei N, et al. Behçet’s syndrome as a tool to dissect the mechanisms of thrombo-inflammation: clinical and pathogenetic aspects. Clin Exp Immunol. 2019 Mar;195(3):322–33.
Yavuz S, Akdeniz T, Hancer V, Bicakcigil M, Can M, Yanikkaya-Demirel G. Dual effects of testosterone in Behcet’s disease: implications for a role in disease pathogenesis. Genes Immun. 2016 Sep;17(6):335–41.
Liu C, Wang Y, Wu Z, Tang X, Wang G, Wang J. Exploration of effective biomarkers for venous thrombosis embolism in Behçet’s disease based on comprehensive bioinformatics analysis. Sci Rep. 2024 Jul 10;14(1):15884.
Ucar-Comlekoglu D, Fox A, Sen HN. Gender differences in Behçet’s disease associated uveitis. J Ophthalmol. 2014;2014:820710.
Seyahi E, Gjoni M, Durmaz EŞ, Akbaş S, Sut N, Dikici AS, et al. Increased vein wall thickness in Behçet disease. J Vasc Surg Venous Lymphat Disord. 2019 Sep;7(5):677-684.e2.
Mattioli I, Bettiol A, Saruhan-Direskeneli G, Direskeneli H, Emmi G. Pathogenesis of Behçet’s syndrome: genetic, environmental and immunological factors. Front Med (Lausanne). 2021;8:713052.
Orlicka K, Barnes E, Culver EL. Prevention of infection caused by immunosuppressive drugs in gastroenterology. Ther Adv Chronic Dis. 2013 Jul;4(4):167-85. doi: 10.1177/2040622313485275. PMID: 23819020; PMCID: PMC3697844.
Özer HTE, Günesaçar R, Dinkçi S, Özbalkan Z, Yildiz F, Erken E. The impact of smoking on clinical features of Behçet’s disease patients with glutathione S-transferase polymorphisms. Clin Exp Rheumatol. 2012;30(3 Suppl 72):S14-17.
Kural-Seyahi E, Fresko I, Seyahi N, Ozyazgan Y, Mat C, Hamuryudan V, et al. The long-term mortality and morbidity of Behçet syndrome: a 2-decade outcome survey of 387 patients followed at a dedicated center. Medicine (Baltimore). 2003 Jan;82(1):60–76.
Alibaz-Oner F, Direskeneli H. Update on the diagnosis of Behçet’s disease. Diagnostics (Basel). 2022 Dec 23;13(1):41.
Chandrashekar A, Garry J, Gasparis A, Labropoulos N. Vein wall remodeling in patients with acute deep vein thrombosis and chronic postthrombotic changes. J Thromb Haemost. 2017 Oct;15(10):1989–93.
Kara Kivanc B, Gönüllü E, Akay OM, Ertürk A, Bal C, Cansu DÜ, et al. Why are male patients with Behçet’s disease prone to thrombosis? A rotational thromboelastographic analysis. Clin Exp Rheumatol. 2018;36(6 Suppl 115):63–7.
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Copyright (c) 2025 Fatih Öner Kaya, Yaser Abdou, Ghayda Jarrar, Mohammad Jamal Abunawas, Yare Sahin
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